Determination of Non-Organ Specific Autoantibodies in Patients with Chronic Hepatitis C and Association with HLA DRΒ1 (*04) Allele

The regulation of immune mechanisms is controlled by major histocompatibility complex/human leukocyte antigen (MHC/HLA). Polymorphisms the HLA region have an impact on susceptibility to complex infectious and autoimmune diseases. present study was carried out determine frequencies ASMA, AMA, ANA, dsDNA, anti-LKM-1 auto-antibodies in hepatitis C patients their association with DRβ1 (*04) locus. It a cross-sectional, analytical study, 86 chronic HCV were recruited. presence (ASMA, anti-LKM-1) determined indirect immunofluorescence ELISA, while allele assessed sequence-specific conventional PCR. ANA detected 41%, ASMA 17.4%, AMA 7%, LKM-1 5.8% dsDNA 4.6% CHC HLA-DRβ1 3.5% patients, but this not significantly associated these auto-antibodies.